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Phase 1b/2a results (published in The Lancet, 2025): - In 125 adults with overweight or obesity, the subcutaneous 20 mg dose achieved 22.0% absolute weight loss (23.9% placebo-adjusted)

Gastrointestinal side effects like mild nausea or slight constipation typically peak around day 3-4 before subsiding, though individual experiences vary widely

741 Scheijen, J

Eur J Heal Econ
