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First, almost every included study did not consider thyroid events as the main result, only regarded them as safety results and did not monitor the changes in thyroid function at the same time

The glucagon receptor stimulation increases energy expenditure and promotes fat breakdown in the liver

A GIP receptor agonist enhanced Bcl-2 levels and reduced BAX levels in the MPTP mouse model of PD [154, 155]

Similarly, ICV injection of Ex-4 increased c-fos expression in alpha-melanocyte stimulating hormone (alpha-MSH)-immunoreactive neurons in the ARC of mice (Dalvi et al., 2012)