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In a recent meta-analysis of 60 clinical studies, GLP-1R agonists were demonstrated to reduce diastolic BP with a range of 1.84 to 4.60 mmHg and to slightly increase heart rate by 23.35 beats/min [620]

[49] further noted that GLP1R is widely expressed in retinal endothelial cells, and its activation significantly inhibits the expression and secretion of multiple inflammatory factors such as TNF- and IL1, reducing immune cell infiltration

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research

3 DAs should be used conservatively in older patients or patients with cognitive problems or dementia, due to the increased likelihood of developing intolerable adverse effects

Research shows it stimulates GLP-1 secretion from intestinal L-cells, the same cells that produce the body's natural GLP-1 hormone