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The Phase 3 TRIUMPH-4 trial recorded 39.4% of participants achieving 30% or more weight loss at the 12mg dose over 68 weeks

A human study showed that GLP-1 significantly delayed gastric emptying but did not affect gastric muscle contractility or water homeostasis, suggesting GLP-1 inhibits gastric emptying through an indirect mechanism rather than altering muscle contractility directly [121]

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This can result in testicular shrinkage (since the testes produce testosterone) and infertility