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They saw significant increases in the levels of lac-phe in people after metformin compared with their levels before treatment

Statistical analysis Statistical analyses were performed with SPSS v.24 (IBM, NY, USA) and customized SPSS syntax routines

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Incremental cost-effectiveness ratios were estimated at $53,400 per quality-adjusted life year gained for tirzepatide, $61,400 for injectable semaglutide, and $69,300 for oral semaglutide