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If you notice that early dosing, which was previously well-tolerated, starts producing nausea after significant weight loss, the changing pharmacokinetics of your lighter body may be the explanation
Patients on semaglutide or tirzepatide should intentionally maintain consistent water intake throughout the day, aiming for at least 2 to 3 liters unless otherwise advised by their healthcare provider

doi: 10.1001/archinte.149.9.1942
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