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Tolerability, Side Effects, and Who Should Consider Each Option Gastrointestinal side effects (nausea, vomiting, constipation) occur more frequently with tirzepatide due to stronger receptor activation and GIPR effects

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Combined with diet and exercise, semaglutide can help you drop excess fat and reach a healthy weight

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This is particularly important in patients receiving lithium, which is known to affect thyroid physiology
