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Between 2023-2025, the NHS faced supply issues with glucagon-like peptide receptor agonists (GLP-1 RAs, or GLP-1 analogues), a range of drugs used for managing blood glucose levels in people with type 2 diabetes

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Rybelsus side effects The most common side effects of Rybelsus are: Nausea Stomach pain Diarrhea Poor appetite Vomiting Constipation Although rare, some people taking Rybelsus may experience serious side effects: Severe allergic reaction Kidney problems Gallbladder problems Low blood sugar (hypoglycemia) Pancreatitis (inflammation of the pancreas) Diabetic retinopathy in patients with Type 2 Diabetes Thyroid tumors, including medullary thyroid carcinoma, a rare but serious condition Warnings Rybelsus has a black box warning from the FDA for the risk of thyroid tumors or thyroid cancer