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The demonstration of the GLP-1 receptor and its expression on the beta cells was of course consistent with its powerful insulinotropic effects (89) and was soon followed by a large number of cell biological studies of its effect on beta cell biology (90)

In an Italian family where several members are obese it was found that a missense mutation was present in their CART gene

Exendin-4 and DPP-4 deficiency prevented vasoconstriction and multiple organ injury after LPS treatment, and improved survival in endotoxemic rats (31)

References This article is based on research from peer-reviewed medical journals, FDA documentation, manufacturer prescribing information, and clinical guidelines

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