does glp-1 really work Drugs for Weight Loss & Diabetes: Here's How It Works Why GLP-1 Drugs Alone Aren't
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2024;165(11):bqae128

and primary MACE endpoint

Novo Nordisk achieved this with semaglutide, a molecule structurally optimized for extreme durability
520,526 In the context of T2DM, liraglutide, by regulating the PI3K/Akt pathway and activating GLP-1R, effectively inhibits the growth and spread of pancreatic cancer cells

However, the A1C reduction is moderate compared with GLP-1 receptor agonists or SGLT2 inhibitors
