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Timing: Flexible

Failure to identify the responsible drug can lead to significant delays in treatment, potentially resulting in critical outcomes (Jones et al., 2015)

Abstract Glucagon-like petide-1 (GLP-1) potentiates insulin and suppresses glucagon secretion from the pancreas in response to the ingestion of nutrients

This piece of evidence suggests that GLP-1 may induce late metabolic changes, not yet elucidated, downstream to HIF-1 activation

However, in the Phase I/II ACTION-Galactosemia study, which focused on adults, treatment with govorestat resulted in a drop in galactitol concentrations, according to Applied Therapeutics
