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Semaglutide oral tablets (Rybelsus ), with 94% homology to human GLP-1, were approved in 2019 as the first GLP-1R agonists for oral administration (Andersen et al., 2021)

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These treatments are often prescribed under medical supervision for long-term use to help with weight management

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A patient carrying specific GLP1R variants, for instance, may require different semaglutide dosing strategies than someone without those variants

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10.3389/fmed.2020.00237 118 RuanZ.LiuJ.ZhaoJ

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Insulin release is higher after enteral, but not intravenous, glucose administration

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