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These individuals appear to have a puzzling condition called GLP-1 resistance, where their bodies produce higher levels of the hormone targeted by these drugsbut dont respond to it properly.

The concept of type 2 diabetes remission is evolving rapidly, and gaining wide public and professional interest, following demonstration that with substantial intentional weight loss almost nine in ten people with type 2 diabetes can reduce their HbA1c level below the diagnostic criterion (48 mmol/mol [6.5%]) without glucose-lowering medications, and improve all features of the metabolic syndrome

Amazon.com: GLP-1 Without The Hype: A no-nonsense guide to sorting facts, fear, side effects, and expectations (The Without the Hype Series): 9798243832656: Everheart, T.L., Busse, Teri: Books