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In addition, a head-to-head trial of semaglutide and liraglutide was conducted in the STEP 8 trial, with a mean weight loss of 17.1% in the semaglutide group, which was significantly more effective than liraglutide (mean weight loss of 6.6%)
By dampening inflammation and modulating microglial activity, GLP-1 RAs create a neuroprotective environment that supports neuronal survival [78]
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