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[DOI] [PMC free article] [PubMed] [Google Scholar] 153

New antidiabetic and anti-obesity drugs

These medications work by mimicking the action of naturally occurring GLP-1 , a hormone released by the intestine in response to food intake

General BMI Considerations GLP-1 medications are generally indicated for adults with obesity (BMI of 30 or higher) or adults with overweight (BMI of 27 or higher) who also have at least one weight-related health condition

However, the ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial found that the once-daily GLP-1 receptor agonist lixisenatide had a neutral effect on cardiovascular outcomes, neither increasing nor decreasing incidence relative to placebo (31)