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GLP-1 immunoreactive fibers directly innervate hypophysiotrophic corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN), placing GLP-1 in prime position to integrate hypothalamo-pituitary-adrenocortical responses

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Daniel Drucker [Biomarker April 2023] Early Days of Weight Loss Therapies Early Days of Weight Loss Therapies In the late 1800s, thyroid extract was used to speed up metabolism and induce weight loss
