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Description
Tirzepatide is a dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist given as a weekly subcutaneous injection, approved in the US for treatment of T2D in 2022 and for chronic obesity treatment in 2023

Studied in models involving GLP-1 receptor activity, incretin signaling, glucose-response biology, and metabolic regulation

Severe kidney disease or a history of pancreatitis

Semaglutide reprograms macrophages via the GLP-1R/PPARG/ACSL1 pathway to suppress papillary thyroid carcinoma growth

M.CherickF.Caroli-BoscF
