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Weight management formulations (Wegovy, Saxenda) also carry warnings about suicidal ideation and behavior

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Takeaway: Hair shedding is typically linked to nutritional and metabolic changes during weight loss, not a direct effect of the medication itself

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Suspected adverse reactions should be reported via the MHRA Yellow Card scheme

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The best designed study to date is a systematic review of 80 randomized clinical trials involving 107,860 participants, which found no association with GLP-1RA treatment and serious psychiatric adverse effects: major depression, suicide, or psychosis (105)

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Treatment with survodutide also showed meaningful metabolic improvements, including reductions in waist circumference, a key predictor of cardiometabolic risk

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