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If bolus insulin is required, it should be initiated using a stepwise approach [103], starting with 1 injection at the largest meal and then introducing additional mealtime injections later if needed (see Figure 2)

Like other GLP-1 medications, retatrutide carries a warning about thyroid C-cell tumors

3033 However, the application of SGLT-2i in some studies has been reported to significantly increase total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C), and high-density lipoprotein cholesterol (HDL-C) and decrease triglyceride (TG)

But significant weight loss will generally take longer

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