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Treatment with Lira significantly reversed the behavioral changes as it depicted an increase in the total distance traveled by mice, mean speed, time being mobile, and rearing frequency (OFT test) reaching levels approximately 4-, 3-, 3- and 4-fold, respectively, greater than those in the cuprizone-treated group

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In addition, GLP1 is also expressed in pancreatic alpha cells, where it exerts local insulinotropic actions 27

Cyclodextrin coformulations with SGLT2 and incretin peptides