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doi: 10.1016/j.regpep.2004.06.020 50 MentleinRGallwitzBSchmidtWE

Moreover, conditioned media from activated fibroblasts and exogenous lactate have been shown to trigger the expression of profibrotic genes in macrophages by inducing histone lactylation [17]

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It was independently identified in the 1980s by two research groups, including one led by Danish physician and physiologist Jens Juul Holst, MD, DMSc, at the University of Copenhagen