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Furthermore, the study confirms the pharmacokinetic compatibility of semaglutide for once-weekly dosing and corroborates recent phase II study results, with regard to improved glycemic control and reduced body weight, in combination with a low risk of hypoglycemia

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Taking into account an estimated 10% dropout rate, we plan to recruit 60 participants in total, allocated 1:1 to the experimental and control groups, which is considered sufficient to assess feasibility, safety, and preliminary efficacy, and to inform the sample size calculation of future large-scale randomized controlled trials

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