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Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf

These medications aren't cheap, aren't always easy to access and can come with side effects

Crucially, NHS prescribing of GLP-1 medications is subject to strict eligibility criteria and typically requires specialist initiation or shared care arrangements

GLP-1 is an endogenous incretin peptide hormone produced from intestinal L-cells predominantly located in the terminal ileum

Furthermore, GLP-1 RAs exhibit anti-inflammatory effects, lowering circulating levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6, while promoting anti-inflammatory mediator production [26]