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Liraglutide in apoE / mice reduced body weight as well as suppressed macrophage-driven atherosclerosis
So Lillys obesity strategy looks less like a single-product story and more like a portfolio strategy: multiple mechanisms, multiple formats, and multiple clinical questions
Several companies already have novel drug candidates in the late stages of clinical trials that offer weekly or monthly dosing options instead of daily injections
Lateral allosterism in the glucagon receptor family: Glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation
Lancet 387 , 679690 (2016)
