surmount 5 tirzepatide as Compared with Semaglutide for the Treatment of Obesity: @NEJM 🥸 SURMOUNT-5 Trial: Wow! 😱 Summary 👇👇👇 Understanding SURMOUNT-5 trial about using

Rapid-acting insulin analogues may be considered over short-acting (regular) insulin to reduce the risk of hypoglycemia [104-107] [Grade B, Level 2]

It is a tolerance window, a safety margin that accounts for real-world handling

Stop using Wegovy and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting

They may suggest checking your levels more frequently or adjusting the timing of your medications

Mechanistic data on GLP-1R/GIPR/GCGR tri-agonists The combination of GLP-1RA, GIPRA, and GCGRA in preclinical studies has demonstrated superior weight loss relative to liraglutide in mice with diet-induced obesity, attributed to decreased food intake and increased energy expenditure (Baggio & Drucker 2021)