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A clinically significant interaction exists between tirzepatide and oral contraceptives, requiring backup contraception for 4 weeks after initiation and each dose increase, and patients taking levothyroxine or other time-sensitive medications warrant closer monitoring

doi: 10.1001/jama.1987.03390070069025

One of the key features of neuropathic pain is central sensitization, where the CNS becomes hyper-responsive to pain stimuli [105]
