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The significant increase in GLP-1RA adoption further highlights the need to provide evidence-based recommendations for GLP-1RA treatment

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

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Patients should seek immediate medical attention for severe persistent abdominal pain (possible pancreatitis), right upper quadrant pain with fever (possible gallbladder disease), severe vomiting leading to dehydration, decreased urine output (possible acute kidney injury), or significant vision changes (possible diabetic retinopathy complications)