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In a study of more than 1,600 adults with type 2 diabetes, those who received the highest dose of orforglipron on average shed 10.5% of their weight.

Furthermore, the ad also provoked two senators, a Democrat (Dick Durbin, D-IL) and Republican (Roger Marshall, MD, R-KS), to write the FDA a letter expressing the legislators concerns about the lack of safety information in the ad threatening potential enforcement action

Prescription rates of SGLT2 inhibitors and GLP-1 receptor agonists among adults with type 2 diabetes in the Veterans Health Administration varied by race, with white patients most likely to receive these medications