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This effect is achieved by reducing the expression of Trem2 and NFATc1 and downregulating the expression of CTSK and TRAP to inhibit bone resorption activity

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These biomarkers include leptin, chitinase-3 like-protein-1 (YKL-40), growth differentiation factor 15 (GDF-15), and intercellular adhesion molecule 1 (ICAM-1)

Week 1-4: 0.25 mg once weekly Weeks 5-8: 0.5 mg once weekly Weeks 9-12 (if needed): 1 mg once weekly, if further glycemic control is required Week 13 onwards (if needed): 2 mg once weekly, if your body can tolerate the previous dosage and further glycemic control is required This medication is started at 0.25 mg per week until you reach the maintenance dose

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