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Therefore, it is speculated that GLP-1 can indirectly affect bone metabolism by regulating the level of blood glucose (Terzi et al., 2015)

Hayes added that his lab has a paper under review looking at sex differences in response to GLP-1R agonists and how the estrous cycle affects the expression of the GCG gene, which codes for preproglucagon, and the GLP-1 receptor gene

When looking at the efficacy regardless of if all patients stayed on treatment, an average weight loss of about 14% (13.6%) was achieved by people taking Wegovy pill compared to about 2% (2.4%) for placebo

While the 122 patent expires on March 20, 2026, its related patent, 343, will expire over five years later on December 5, 2031

October 23, 2025
