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The introduction of tirzepatide, the first dual agonist targeting both the GLP-1R and the glucose-dependent insulinotropic polypeptide (GIP) receptor, represents a new frontier in incretin-based therapy (Syed, 2022

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Combination therapy in PCOS has demonstrated additive benefits on weight and menstrual cyclicity, highlighting synergistic mechanisms rather than direct reproductive pharmacodynamics

Acknowledgements The authors thank the FILM Facility, Imperial College London for technical support on microscopy experiments and microscopy data analysis, and Prof Mark Sansom and Dr Wanling Song, Dept Biochemistry, University of Oxford, for assistance with the use of PyLipID for the GLP-1R-cholesterol binding site analysis