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Physiology of the weight-loss plateau in response to diet restriction, GLP-1 receptor agonism and bariatric surgery

Healthcare economists note that the current pricing structure creates access barriers for patients seeking these medications, particularly those without comprehensive drug coverage

Sensory signal transduction in the vagal primary afferent neurons

The following table includes established risk factors that can be influenced, for example, by adopting a healthy diet and lifestyle, intervening with targeted nutrients, and using medications when appropriate

The shorter trial duration of SUSTAIN 6 and PIONEER 6 compared with the 3.5-year trial duration of LEADER might also explain the observed discrepancy in treatment effect across baseline eGFR subgroups [2], because eGFR decline is a continuous process and a follow-up of 2 years is recommended to reliably predict a treatment effect based on changes in eGFR slope [26]