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Description
We report the use of GLP-1RA therapy with liraglutide and subsequent transition to subcutaneoussemaglutide weekly in a 37-year-old female with severe obesity, weighing 694 lbs (314 kg) with a body mass index (BMI) of 108 kg/m2
GI side effects were slightly more common but mostly mild to moderate and occurred during dose escalation
Side effects like nausea, vomiting, and diarrhea especially common in the first weeks of treatment or after dose increases can further deplete fluids
GLP-1 receptor agonist
Neoepitopes were identified in DS and DP semaglutide follow-ons, indicating potential immunogenicity
