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Some people may feel more emotional or irritable as a result

Patients should report persistent or severe headaches to their healthcare provider

This led to the hypothesis that reversing the progression of hypoxia could lead to improved kidney function [15]

On the other hand, similar results were also seen with the phentermine/topiramate in severely obese adults (EQUIP) study, in which obese adults were randomized in three groups to receive either placebo (n=514), phentermine/topiramate 3.75 mg/23 mg (n=241) or phentermine/topiramate 15 mg/92 mg (n= 512) in conjunction with the standard lifestyle modifications as standard of care

[6] [8] Gastrointestinal side effects collectively represent the most frequent category of adverse reactions associated with GLP-1 receptor agonists