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In the low-glucose (0.1 mM) state, DCA-stimulated GLP-1 secretion was completely inhibited by 1-M pasireotide treatment, paralleling the cAMP levels in GLUTag cells (Fig

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Many patients get discouraged during the first month because the starting dose may not produce dramatic appetite suppression or weight loss

Meanwhile, Mojsov had also begun supplying peptides and other reagents to another Habener postdoc assigned to unraveling the GLP-1 mystery, an endocrinologist named Dan Drucker

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