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too much self-renewal would result in germline tumors of proliferating cells and a reduction or elimination of differentiated gametes that are formed, while too much differentiation would result in the GSC population being depleted and a lack of sustained gamete formation

A recent study also found that tri-agonist treatment was able to ameliorate diet-induced steatohepatitis in mice 77

Key markers include: When to adjust your dose Consider staying at current dose if: You are losing 1 to 2 pounds per week consistently, side effects are tolerable, and you feel good

Constipation can occur due to slower digestion

Am J Med 130:5156 Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kber LV, ELIXA Investigators et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome