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Yes, for most people, the fatigue is temporary and occurs most notably during the first few weeks of treatment or after a dose increase

Additional assessment and/or laboratory testing may be indicated prior to therapy based on recent or current use of a very lowcalorie diet, prior bariatric surgery, celiac disease, other inflammatory conditions predisposing to nutrient deficiency, or prior nutrient deficiency [57, 128]

Understanding GLP-1 How It Supports Weight Loss, Type 2 Diabetes, and Why IV Therapy Makes a Difference What is GLP-1

doi: 10.1503/cmaj.101281 Summary Keywords sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, type 2 diabetes, metformin, meta-analysis Citation Deng R, Mei K, Song T, Huang J, Wu Y, Yu P, Yan Z and Liu X (2024) First-line treatment with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists in type 2 diabetic population at low risk of cardiovascular disease: a meta-analysis
