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Hormonal birth control: If you are using an oral hormonal contraceptive (birth control), Zepbound may decrease its efficacy, especially after the first dose

This approach is designed to meet regulatory expectations and, at the same time, reduce two foreseeable risks: inadvertent early pregnancy exposure and metabolic rebound after cessation
Sitagliptin inhibits DPP4, the enzyme that breaks down incretin hormones

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