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The mode of action for AMG133 is believed to involve this bispecific molecule simultaneously binding to both the GIP- and GLP-1 receptor, where it is demonstrated to increase cAMP production and induce internalization of co-localized GIP and GLP-1 receptors

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doi: 10.2147/JIR.S309427 26 XieLXiaoYTaiSYangHZhouSZhouZ

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Further analysis was carried out using the SimFCS 4 Software to determine the RICCS cross-correlation between Laurdan and SNAP/FLAG-hGLP-1R