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In order to transfer preclinical knowledge about tissue-specific sources of Gcg peptides to improve upon current pharmacotherapies for type 2 diabetes, it is important to understand what stimuli provoke paracrine communication within the pancreas

Protein provides the most satiety per calorie of any macronutrient

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The so-called incretin effect describes this phenomenon and also explains that orally ingested glucose leads to a higher insulin response than intravenously administered glucose leading to isoglycemic glucose excursions compared to oral glucose (32)

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