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Save the date Make plans to join us June 1821, 2027, for the 2027 Scientific Sessions at the Walter E

Research Insight The project illustrated how triple-receptor signaling can provide valuable information when studying liver physiology, lipid metabolism, and integrated metabolic regulation in preclinical models

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Notably, mutations in the GLUT2 gene affect the glucose-lowering efficacy of metformin (Zhou et al., 2016), which may be one of the reasons for individual differences in metformin efficacy

Some data suggest that pharmacological inhibition of sweet taste receptors blunt GLP-1 responses to nutrients (217), but other studies found no impact of sweet taste receptor agonists on GLP-1 secretion in humans (146, 178) or in in vivo or ex vivo studies in rats (208)