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This profile supports once-weekly subcutaneous administration, similar to other long-acting GLP-1-based therapies already in clinical use

The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent

While evidence suggests GLP-1 receptor agonists have protective effects against arterial disease, the evidence specifically examining venous thrombosis risk is more limited, though no safety signals have emerged

This anxiogenic role of GLP-1 is likely tightly linked with the role brain GLP-1Rs play in interoceptive stress responses (108, 111)
