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Additionally, a small retrospective series described 17 patients with perianal fistulizing CD treated with a GLP-1RA, reporting improvements in fistula drainage and pain scores

PMID 29028590

Tirzepatide (Zepbound) Tirzepatide is a dual GIP/GLP-1 receptor agonist activating two separate hormone pathways simultaneously

This eliminates the financial burden of chasing combination protocols when optimized monotherapy may suffice

Written by: MedExpress Medically reviewed by: Dr Sophie Dix Published: 28 February 2025 | Updated: 6 February 2026 Updated: 6 February 2026 Reading time: 4 minutes Quick navigation: How GLP-1 medications are reshaping confidence, intimacy, and relationships Key takeaways How GLP-1 medications impact confidence, intimacy, and relationships The role of sexual health and social pressures in the GLP-1 weight-loss journey The lasting impact of GLP-1 medications on confidence and relationships Methodology About MedExpress Fair use statement How GLP-1 medications are reshaping confidence, intimacy, and relationships Weight loss is often seen as a physical transformation, but for many, its impact goes far beyond the scale