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At the N-terminus, the Tyr1 of Tirzepatide makes Van der Waals contact with the receptor residues, the Glu3 forms an ionic bond with Arg183 and a network of hydrogen bonds with Tyr145 and Ser381 of the receptor

Glycine helps preserve muscle, but it is not magic

For pharmacy practice, this translates to complex polypharmacy, adherence challenges, and a need for careful medicines optimisation to avoid iatrogenic weight gain, ie, weight gain caused by medicines such as antidepressants

Plateaus don't mean failure - adjusting your dose or combining treatments may help you continue losing weight

These non-standard concentrations require their own conversion tables