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Data from randomised controlled trials suggests that you do lose some lean mass when on Mounjaro, but this is normal and expected

Discover whether Semaglutide, a weight loss medication, might cause tiredness

In a phase 2 study, amycretin showed a mean weight reduction of up to 24.3%, which is comparable to or even greater than the weight loss seen with tirzepatide and similar to the results for retatrutide

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Even Halle Berry agrees.
