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If you or someone youre helping is dual-eligible, this is an important avenue to explore

High-fat diet induced alterations in plasma membrane cholesterol content impairs insulin receptor binding and signalling in mouse liver but is ameliorated by atorvastatin

Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)

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This was confirmed by the elution of a quality control standard spiked with semaglutide