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Quick Answer: GLP-1 injections last between 24 hours and one week per dose depending on the formulation, with short-acting versions like exenatide clearing within a day and long-acting options like semaglutide remaining therapeutically active for approximately seven days

Faster absorption means more semaglutide reaching GLP-1 receptors in a shorter time window, and those receptors in the brain and gut respond accordingly

GLP-1 receptor agonists have been prescribed (on-and-off label) for weight management, including obesity, along with a reduced caloric diet and increased physical activity

Wegovy (Injection) Adults and children age 12 and older with obesity (a body mass index, or BMI, of 30 or higher) Adults and children age 12 and older who are overweight (a BMI of 27 or higher) and have at least one weight-related condition, such as high blood pressure, high cholesterol or triglycerides, or type 2 diabetes Wegovy (Pill) Adults with obesity Adults who are overweight and have at least one weight-related comorbid condition Adults with established heart disease who either have obesity or are overweight Zepbound Adults with obesity Adults who are overweight and have at least one weight-related condition Dosage Weight Loss Other Benefits Beyond weight loss, both medications offer additional health benefits, says Dr