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Genetic studies suggest an increased ED risk with gliclazide [154], possibly due to SU-mediated inhibition of ATP-sensitive potassium channels essential for prostaglandin E1 (PGE1)- and cAMP-dependent vasodilation [155]

Patients experiencing nausea should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that may exacerbate nausea Stay well-hydrated with small, frequent sips of water Consider bland foods such as crackers, toast, or rice during symptomatic periods Avoid lying down immediately after eating For constipation , increasing dietary fibre intake through fruits, vegetables, and whole grains, alongside adequate fluid consumption (1.5-2 litres daily), often provides relief

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- **Curb appetite:** Helping individuals feel full, potentially leading to reduced food intake

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