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Legend for network figures and content description of Supplementary data 2 is in Supplementary File 1

Practical management strategies For nausea: Eat smaller, more frequent meals (5-6 small meals instead of 3 large ones) Avoid fatty, greasy, and spicy foods, especially during the first week after each dose increase Ginger tea or ginger chews can provide natural relief Take the injection on a day when you can rest if the nausea is severe Stay hydrated

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