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In addition to GLP-1 and ATP, for example, GLUTag cells also secrete several other peptide hormones 36 including CCKa known stimulus of Ca 2+ -responses in ND ganglion neurones 37 as well as glutamate 38 , which has been reported to target NMDA receptors on the afferent vagus 39 and to underlie L-cell to nodose neuron signalling 40